CALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Chronic Tempol treatment restores pharmacological preconditioning in the senescent rat heart
نویسندگان
چکیده
Jiang Zhu, Mario J. Rebecchi, Qiang Wang, Peter S. A. Glass, Peter R. Brink, and Lixin Liu Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; Department of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, New York; Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China; and Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, New York
منابع مشابه
Chronic Tempol treatment restores pharmacological preconditioning in the senescent rat heart.
Cardioprotective effects of anesthetic preconditioning and cyclosporine A (CsA) are lost with aging. To extend our previous work and address a possible mechanism underlying age-related differences, we investigated the role of oxidative stress in the aging heart by treating senescent animals with the oxygen free radical scavenger Tempol. Old male Fischer 344 rats (22-24 mo) were randomly assigne...
متن کاملThe Effect of Verapamil Administred before the Reperfusion Insult in Isolated Preconditioned Rat Heart on the Microsomal ATPase and Mitochondrial Enzyme Activities
Background: Calcium overload and free radical mediated damage in the mitochondria is the most important pathological changes associated with myocardial ischemic-reperfusion injury. The verapamil post-treatment has been previously reported to prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depression effect. In the...
متن کاملThe effects of cinnamon on risk factors of cardiovascular disease
Introduction: Herbal medicine is being considered today due to the side effects and high prices of chemical medicines. Cinnamon appears to be effective in the prevention and treatment of a variety of diseases, both as a food spice and in traditional medicine. We attempted to collect the effects of cinnamon on the occurrence of cardiovascular disorders and their related parameters in this review...
متن کاملCALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Mitochondrial reactive oxygen species: which ROS signals cardioprotection?
Garlid AO, Jaburek M, Jacobs JP, Garlid KD. Mitochondrial reactive oxygen species: which ROS signals cardioprotection? Am J Physiol Heart Circ Physiol 305: H960–H968, 2013. First published August 2, 2013; doi:10.1152/ajpheart.00858.2012.—Mitochondria are the major effectors of cardioprotection by procedures that open the mitochondrial ATP-sensitive potassium channel (mitoKATP), including ischem...
متن کاملEffect of antihypertensive agents - captopril and nifedipine - on the functional properties of rat heart mitochondria
Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013